Reprint of: Virus-Specific T Cells: Broadening Applicability
نویسندگان
چکیده
منابع مشابه
Optimization Manufacture of Virus- and Tumor-Specific T Cells
Although ex vivo expanded T cells are currently widely used in pre-clinical and clinical trials, the complexity of manufacture remains a major impediment for broader application. In this review we discuss current protocols for the ex vivo expansion of virus- and tumor-specific T cells and describe our experience in manufacture optimization using a gas-permeable static culture flask (G-Rex). Thi...
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The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is unexplained. One factor may be the low frequency and immature phenotype of virus-specific CD8(+) T cells. The role of CD4(+)CD25(+) T regulatory (T(reg)) cells in priming and expanding virus-specific CD8(+) T cells was investigated. Twenty HLA-A2-positive patients with persistent HCV infection and 46 healt...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2018
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2017.12.787